

S-Adenosylmethionine (SAMe), derived from methionine, is a universal methyl donor involved in methylation reactions. These reactions are crucial for DNA synthesis, mental health, and detoxification. SAMe also supports joint health, cancer management and mood regulation, making it a valuable compound for managing conditions like depression, osteoarthritis, and liver disease. SAMe levels reflect the body’s ability to methylate, and testing SAMe can help identify potential methylation deficiencies or imbalances.
S-Adenosylhomocysteine (SAH) is a precursor to homocysteine and a byproduct of SAMe-dependent methylation reactions. Elevated SAH levels can indicate impaired methylation efficiency, potentially contributing to various health issues, including cardiovascular disease and neurological conditions.