The simple cheek swab test provides personalised insights into your health across the following areas:
-Cardiovascular Health -Metabolism & Weight Management -Emotional & Psychological Wellbeing -Nutrition & Gut Health -Food Intolerances -Drug Metabolism -Musculoskeletal stability
This myDNA Comprehenisve Check covers an extensive 42 genes and 47 SNPs and is performed by an Australian NATA-accredited laboratory. Your results are analysed by our local team of molecular biologistics, data scientists and clinicians to provide your personalised report.
Your genes are the master plan for how your body runs, but your environment—like diet, exercise, and toxin exposure—can tweak that plan for better or worse. Think of it as having the build of a Skoda but being able to drive like a Porsche. Discover how to fine-tune your body's inner workings for peak performance and ultimate well-being. Ready to level up?
What we test
myDNA Genes Covered
Apolipoprotein E (APOE) is a lipid-binding protein involved in transporting triglycerides and cholesterol, with the APOE-e4 allele being a significant genetic risk factor for Alzheimer’s disease. However, other epigenetic factors also play a significant role.
Apolipoprotein E (APOE) is a lipid-binding protein involved in transporting triglycerides and cholesterol, with the APOE-e4 allele being a significant genetic risk factor for Alzheimer’s disease. However, other epigenetic factors also play a significant role.
Celiac disease is an immune reaction to gluten, a protein in wheat, barley, and rye. While about 30% of people have variants in the celiac risk genes HLA-DQA1 through HLA-DQB, only ~3% develop the condition.
Celiac disease is an immune reaction to gluten, a protein in wheat, barley, and rye. While about 30% of people have variants in the celiac risk genes HLA-DQA1 through HLA-DQB, only ~3% develop the condition.
Mutations in the HFE C282Y gene can cause iron overload by increasing iron absorption and disrupting metabolism. Homozygotes account for most hemochromatosis cases, while those with one mutation have a lower risk but may still benefit from further testing if there’s a family history.
The LPA I4399M gene variant is a change in the LPA gene that can increase the risk of heart disease by raising levels of a protein called lipoprotein (a), which can lead to the buildup of plaques in arteries.
The PON1 gene encodes paraoxonase 1, an enzyme that protects cells from oxidative damage by attaching to HDL particles. The Q192R mutation alters the enzyme's efficiency, potentially increasing the risk of heart disease and inflammation.
The PPAR-alpha rs1800206 gene variant is a change in the PPARA gene, which helps regulate how the body uses fats for energy. This variant can affect fat metabolism and influence the risk of developing type 2 diabetes and heart disease.
The APOA2 T-265C gene variant has been associated with differences in body mass index (BMI) and food intake, potentially influencing obesity risk and dietary habits.
The GPX1 gene encodes glutathione peroxidase 1, an enzyme that protects cells from oxidative damage. This variant can reduce the enzyme's efficiency, increasing the risk of oxidative stress-related conditions like diabetes complications and certain cancers.
A COMT mutation can change how quickly your body breaks down dopamine, adrenaline, and noradrenaline - this can affect neurological systems that regulate mood, cognitive function, and stress.
Similar to PEMT C744G, this mutation is also associated with lower choline production in the liver. Both PEMT variations can lead to lower phosphatidylcholine levels, which may increase the risk of fatty liver disease and issues with fat metabolism.
This mutation is associated with lower choline production in the liver. Choline is essential for production of acetylcholine which helps send messages through to various organs, ensuring smooth communication within our nervous system and proper functioning of our organs.
The LCT C-13910T gene variant affects the lactase enzyme, which breaks down lactose. This variant is linked to lactose intolerance, causing difficulty digesting lactose and leading to gastrointestinal symptoms like bloating, gas, and diarrhoea.
The VKORC12 G-1639A gene variant affects how the body processes vitamin K, essential for blood clotting and bone health. This variant can also influence the dosage of blood-thinning medications like warfarin, as it impacts the enzyme's activity involved in recycling vitamin K.
The CYP2R1 gene, is responsible for converting vitamin D into its active form in the liver. This variant can influence vitamin D levels in the body, with certain alleles associated with lower vitamin D levels and potential vitamin D insufficiency.
The methionine synthase enzyme is required to convert homocysteine to methionine. The mutation may reduce enzyme efficiency, potentially contributing to elevated homocysteine levels, especially when combined with other genetic or nutritional factors.
This gene encodes an enzyme essential for regenerating methionine synthase. Similar to MTR, mutations in this gene may impair enzyme function, potentially leading to elevated homocysteine levels.
The FUT2 gene encodes an enzyme that influences blood group antigen secretion and gut bacteria composition. This variant can cause non-secretor status, affecting gut microbiome diversity and increasing susceptibility to infections like norovirus and autoimmune disorders.
The TCN2 gene encodes transcobalamin II, which transports vitamin B12 to cells. The G776C variant can lower transcobalamin levels, reducing vitamin B12 availability and potentially increasing the risk of conditions like peripheral neuropathy.
The 5-HT2A gene encodes the serotonin 2A receptor, which regulates mood and responses to medications. The T102C variant can affect responses to psychotropic drugs and is linked to conditions like schizophrenia and depression.
The 5-HT2A gene encodes the serotonin 2A receptor, which regulates mood and responses to medications. The G-1438A variant can influence receptor expression, affecting the response to antipsychotics and increasing the risk of depression.
The MAO-A gene encodes an enzyme that breaks down neurotransmitters like serotonin, norepinephrine, and dopamine. The R297R variant can affect enzyme activity, potentially increasing susceptibility to psychiatric conditions such as depression and anxiety.
The BDNF gene encodes brain-derived neurotrophic factor, essential for neuron growth and survival. The V66M variant can impair BDNF secretion, leading to memory issues, mood disorders, and an increased risk of neuropsychiatric conditions like depression and schizophrenia.
The NBPF3 gene is associated with the synthesis of a hormone involved in the clearance of vitamin B6 from the body. Variants can lead to lower levels of vitamin B6 in the blood, which is important for neurological function, red blood cell production, and sugar metabolism.
The IL-6 gene encodes the cytokine interleukin-6 (IL-6), which plays a key role in inflammation and immune response. The G-174C variant can lead to higher levels of IL-6 in the blood, increasing the risk of inflammatory conditions.
The TNF-a gene encodes TNF-alpha, a cytokine involved in inflammation and immune response. The G-308A variant may increase TNF-alpha production, raising the risk of inflammatory conditions and cardiovascular diseases.
CYP1A2 is responsible for metabolising caffeine, a stimulant found in coffee, tea, and other beverages. Variations in the CYP1A2 gene can influence the rate at which caffeine is metabolised, affecting its duration of action and potential impact on sleep.
The CYP2C9 gene encodes an enzyme involved in the metabolism of various drugs, including warfarin. The A1075C variant (CYP2C93) affects the enzyme's activity, leading to reduced metabolism of warfarin and an increased risk of bleeding in individuals taking the medication.
The CYP2C19 gene encodes an enzyme involved in the metabolism of various drugs. The C-806T variant (CYP2C1917) increases the enzyme's activity, leading to ultra-rapid drug metabolism and potentially affecting the efficacy and safety of medications.
The CYP2D6 gene encodes an enzyme involved in the metabolism of many drugs, including antidepressants and opioids. The C100T variant (CYP2D610) can lead to increased enzyme activity, affecting how individuals respond to medications.
The CYP3A4 gene encodes an enzyme involved in the metabolism of many drugs and toxins. The A-392G variant (CYP3A41B) can increase the enzyme's activity, potentially affecting drug metabolism.
The ADIPOQ gene encodes the protein adiponectin, which helps regulate glucose levels and fatty acid breakdown. The T45G variant can influence adiponectin levels and is associated with insulin resistance and metabolic diseases.
The MTNR1B gene produces a receptor for melatonin, which regulates sleep-wake cycles. Variants in this gene may raise blood sugar levels, increasing type 2 diabetes risk, and can also affect sleep quality, making it harder to fall or stay asleep.
The TCF7L2 gene encodes a transcription factor involved in the Wnt signalling pathway, which plays a role in regulating blood sugar levels. This variant is associated with an increased risk of type 2 diabetes by affecting insulin secretion and glucose metabolism.
The PPARGC1A gene encodes the protein peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), which is a master regulator of mitochondrial biogenesis and energy metabolism. The G482S variant is associated with an increased risk of type 2 diabetes and metabolic diseases.
The SHBG gene produces sex hormone-binding globulin, which regulates sex hormone levels like estrogen and testosterone. Variations in the SHBG gene can affect SHBG levels, influencing the risk of type 2 diabetes and menopausal symptoms, as well as bone health, muscle mass, and overall well-being.
The SHBG gene produces sex hormone-binding globulin, which regulates sex hormone levels like oestrogen and testosterone. Variations in the SHBG gene can affect SHBG levels, influencing the risk of type 2 diabetes and menopausal symptoms, as well as bone health, muscle mass, and overall well-being.
The ACE1 gene encodes the angiotensin-converting enzyme (ACE), which regulates blood pressure and fluid balance. The rs4343 variant (A2350G) is linked to higher ACE levels with the G allele, potentially impacting blood pressure and cardiovascular risk.
The AGTR1 gene encodes the angiotensin II type 1 receptor, which plays a role in regulating blood pressure and fluid balance. The A1166C variant can increase the risk of hypertension and metabolic syndrome by affecting the receptor's function.
The NOS1 gene encodes neuronal nitric oxide synthase (NOS1), which produces nitric oxide, involved in regulating blood flow and neurotransmission. Variants are associated with an increased risk of developing diabetic nephropathy and an increased likelihood of renal replacement therapy.
The ADRB2 gene encodes the beta-2 adrenergic receptor, which is involved in the body's response to adrenaline and noradrenaline, affecting heart rate, blood pressure, and metabolism. The G16R variant can influence the receptor's function and has been associated with conditions like asthma.
The DIO1 gene converts inactive thyroid hormone (T4) into its active form (T3), which regulates metabolism and energy use. Variants can affect this conversion, potentially altering thyroid hormone levels and metabolic balance.
The VDR gene encodes the vitamin D receptor, which regulates calcium and phosphate levels, affecting bone health and immune function. The FokI variant impacts VDR activity, with the GG variant being more active, potentially influencing vitamin D metabolism and related health outcomes.
The ABCG2 gene encodes a protein that transports substances like drugs and toxins in and out of cells. The Q141K variant reduces this transport, leading to a buildup of uric acid in the blood, increasing the risk of gout and affecting kidney health.
The CYP17A2 gene encodes an enzyme involved in producing steroid hormones like oestrogen and androgens. The T-34C variant can increase the activity of this enzyme, leading to higher levels of these hormones and potentially affecting conditions like hormone-related cancers and metabolic processes.
The GSTM1 gene encodes an enzyme that detoxifies harmful substances like drugs and toxins. The homozygous genotype results in a deleted, non-functional gene, which may increase susceptibility to certain cancers and chemical sensitivities.
Cardiovascular Health
Your genes play a crucial role in cardiovascular health by influencing fat metabolism, inflammation, and artery function. Genes like LPA, APOE, and PPAR-alpha can affect cholesterol levels, plaque buildup, and inflammation, raising the risk of conditions like heart attacks and strokes. Mutations in these genes may lead to elevated LDL cholesterol and increased arterial plaque formation. Our advanced genetic test can help you understand these risks and guide you in fine-tuning your health for peak performance and ultimate well-being.
Metabolism & Weight Management
Your genes significantly influence metabolism and weight management by affecting factors like fat metabolism, liver health, thyroid function, and nutrient absorption. Mutations in genes related to fat metabolism can lead to increased fat storage or conditions like non-alcoholic fatty liver disease (NAFLD) and hinder weight management. Hypothyroidism, often caused by genetic factors, can slow metabolism and lead to weight gain. Additionally, certain gene variants can result in vitamin deficiencies, further impacting metabolic health. Our advanced genetic test can help you understand these genetic factors, guiding you towards optimal weight management and metabolic well-being.
Nutrition & Gut Health
Nutrition and Gut Health are all about the balance between your genes and your environment. Certain genes like HLA, PEMT, MTR, and LCT can determine how your body handles specific foods, affecting conditions like lactose intolerance, IBD (Inflammatory Bowel Disease), and IBS (Irritable Bowel Syndrome). Other genetic variations in genes such as VDR, PEMT, and MTR can also lead to vitamin deficiencies or malabsorption issues, impacting your overall well-being. These imbalances can cause digestive discomfort, nutrient absorption problems, and inflammation. Our comprehensive genetic test helps pinpoint these variations, guiding you to make smart dietary choices and optimise your health.
Stability & Strength
Strength and Stability are the foundation of a healthy, active life. Achieving optimal strength and stability involves understanding how your body’s muscles, bones, and connective tissues work together. Our advanced genetic test provides insights into how your body supports itself, highlighting key factors that impact your strength and stability.
This test includes an analysis of genes and conditions such as Ehlers-Danlos Syndrome (EDS), which affects connective tissue, osteoporosis, which weakens bones, and arthritis which causes joint inflammation and pain. We also look at genetic variants related to nutrient absorption, ensuring that your body gets the vitamins and minerals it needs for strong bones and muscles. By understanding your genetic makeup, you can take proactive steps to enhance your strength and stability for a healthier, more resilient body.
Ready to build a stronger, more stable you? Let's get started!
Psychological & Emotional Wellbeing
Emotional and psychological health is controlled by neurotransmitters, hormones, and neural networks in the brain, which regulate mood, stress, and emotional responses. Genetic factors and clinical biomarkers can impact neurotransmitter and hormone levels contributing to problems like anxiety, depression and stress. The PEMT gene affects phosphatidylcholine synthesis, crucial for brain health, while the COMT gene influences the breakdown of dopamine, affecting mood and cognitive function. Variants in these genes can lead to mood swings, anxiety, and other emotional challenges. Our advanced genetic test can help you understand these genetic factors, guiding you toward optimal mental and emotional well-being.
Cognitive Function
Cognitive Function and Performance is controlled by neural connections and the balance and interaction of neurotransmitters, hormones, and other chemical substances in the brain. These regulate stress responses, overall mental alertness, focus, motivation, memory, learning and problem-solving. These can be impacted by genetic factors (e.g. PEMT, COMT, APOE gene), biomarkers like elevated homocysteine levels, nutrient deficiencies (e.g., vitamin B12), and lifestyle factors such as poor sleep, lack of exercise, and chronic stress. The test can highlight genetic inefficiencies in these areas, helping you understand your risk factors for cognitive decline or chronic inflammation.
Test instructions
Your cheek swab test kit and all instructions are posted directly to you - there is no need to visit a collection centre.
Mail your sample back to the lab using the prepaid envelope and packaging.
Results for this test typically available in 2 weeks and will be published in your online dashboard.
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