The myDNA test covers an extensive 92 genes, and 113 SNP’s across the following categories:
- Digestion
- Energy
- Hormones
- Stress & Cognitive Performance
- Methylation
- Inflammation
- Athletic Performance
- DNA Protection & Repair
- Detoxification
The myDNA report includes a genetic strength and weaknesses summary for each section helps to identify key focus areas for health. Also included is a personalised list that highlights good sources of macro and micronutrient requirements, and suggested blood tests to further analyse certain findings from the DNA test.
A sample of the myDNA report can be viewed here: demo
What we test
Nutrient Metabolism & Digestion
Genetic Methylation
This genetic methylation test includes the essential MTHFR, COMT, MTRR, MTR, MTHFD1, PEMT and CBS methylation genes. Knowing your methylation genotype can uncover needs for nutritional support such as amino acids, vitamins, and minerals and help guide dietary and lifestyle treatment plans.
MTHFR 677 and MTHFR 1298 genotypes determine your folate requirements to assist normal homocysteine levels.
A COMT mutation can change how quickly your body breaks down dopamine, adrenaline, and noradrenaline - this can affect neurological systems that regulate mood, cognitive function, and stress.
This gene encodes an enzyme essential for regenerating methionine synthase. Similar to MTR, mutations in this gene may impair enzyme function, potentially leading to elevated homocysteine levels.
The methionine synthase enzyme is required to convert homocysteine to methionine. The mutation may reduce enzyme efficiency, potentially contributing to elevated homocysteine levels, especially when combined with other genetic or nutritional factors.
MTHFD1 helps convert folate from one form into another which is critical for methylation. Mutations in MTHFD1 may result in lower levels of active folate as well as folate intermediates, which are a key input for crucial making DNA and RNA, and downstream biological pathways.
This mutation is associated with lower choline production in the liver. Choline is essential for production of acetylcholine which helps send messages through to various organs, ensuring smooth communication within our nervous system and proper functioning of our organs.
The CBS gene helps convert homocysteine into important substances for our body, like proteins and antioxidants that fight cell damage. Mutations in this gene can weaken this process, potentially raising homocysteine levels.
MTHFR 677 and MTHFR 1298 genotypes determine your folate requirements to assist normal homocysteine levels.
Folinic acid is a second type of folate found in folate-rich food.
Vitamin B6 plays an important role in homocysteine metabolism and CBS gene function.
Vitamin B6 plays an important role in homocysteine metabolism.
Vitamin B2 plays a special role in stabilising the MTHFR gene for homocysteine metabolism.
Choline and betaine play a crucial role in homocysteine metabolism, especially for those with variants in MTHFR.
Certain genotypes in the folate metabolism pathway can affect the metabolism of synthetic folic acid, leading to high circulating levels.
Hormone Support
There are multiple genes in the estrogen detoxification pathway that have a cumulative value on the ability to properly detoxify oestrogen.
Numerous gene combinations are required to determine a cumulative value of prostate protection.
A combination of genotypes have been associated with low, average and above average testosterone levels.
Pesticides, cadmium, mercury, and arsenic have all been shown to lower GSTP1 expression, increasing the elevation and toxicity of these chemicals and heavy metals. The exposure and sensitivity to these chemicals and heavy metals are suspected reasons for the increased risk of male infertility related to GSTP1 variants.
T3 and T4 level variations have been associated with variants in the DIO1 gene.
Mental Health & Cognitive Performance
Detoxification
Mycotoxins are toxic compounds that are naturally produced by certain types of fungi. Research suggests that mycotoxins can decrease the formation of glutathione due to decreased gene expression of the enzymes needed to form glutathione.
Xenoestrogens are synthetic hormone disruptors found in plastics and pesticides.
Workers exposed to certain chemicals over a long period in the metalworking, petroleum, agricultural industries and in glass factories are at increased risk for occupational skin cancers.
ALDH2 encodes for aldehyde dehydrogenase, and variants can affect the levels of acetaldehyde and therefore the carcinogenic effect of alcohol.
Benzo(a)pyrene is a carcinogenic compound produced from the burning of wood or trash, tobacco smoke, asphalt, coal, diesel exhaust, charred meat, and gas cooking.
Aromatic amines are found in cigarettes, rubber factories, hair dyes that contain 4-aminobiphenyl, and meat cooked at high temperatures.
Aspartame is an artificial sweetener that has been linked to behavioral, neurological and cognitive problems, increased blood sugar, thyroid issues, and certain types of cancer.
Food dyes have been found to inhibit mitochondrial respiration - the ability of the powerhouse of your cells to convert nutrients to energy. They have also been found to especially affect those with ADHD.
Glyphosate is an herbicide that has been found to be highly toxic.
Organochlorines are found in certain pesticides, PCBs and sucralose.
PONI plays a large role in removing pesticides and is also involved with supporting HDL function and LDL oxidation. Organophosphates are a class of insecticides, including parathion and chlorpyrifos, that were among the most widely used insecticides available until the 21st century.
Chemical agriculture uses high amounts of synthetic organophosphates, creating a very high phosphorus content. Synthetic phosphorus concentrates the amounts of heavy metals, like cadmium in non-organic soils and food. Choosing organic produce is one of the best ways to avoid excess cadmium.
Mercury is a neurotoxin linked to neurological and behavioural disorders including tremors, insomnia, memory loss, neuromuscular effects, headaches, and cognitive and motor dysfunction. Burning coal for power and heat is a major source of mercury exposure. Glutathione is responsible for protecting against and detoxifying heavy metals like mercury.
Lead-based paint, lead-based dust in older buildings, contaminated water, and air pollution are the major sources of lead. Exposure to lead over time may cause abdominal pain, constipation, depression, distraction, forgetfulness, irritability, and nausea.
Immune Support & Inflammation
DNA Protection & Repair
Cardiovascular Health
Exercise
Test instructions
Your cheek swab test kit and all instructions are posted directly to you - there is no need to visit a collection centre.
Mail your sample back to the lab using the prepaid envelope and packaging.
Results for this test typically available in 2 weeks and will be published in your online dashboard.
You may also be interested in
DNA Nutrition Assessment
Platinum Health Check - Male
Platinum Health Check - Female
